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Nucleic Acids Research, 1984, Vol. 12, No. 18 6979-6993
© 1984

MOLECULAR BIOLOGY

A human IFN-ß1, gene deleted of promoter sequences upstream from the TATA box is controlled post-transcriptionally by dsRNA

Uri Nir, Batya Cohen, Louisa Chen and Michel Revel

Department of Virology, Weizmann Institute of Science Rehovot, Israel

Received July 17, 1984. Revised September 10, 1984. Accepted September 10, 1984.

Induction of IFN-ß1 RNA was studied in the mouse cell line SR117-21E transformed by a BPV episome containing the human IFN-ß1 gene deleted of promoter sequences upstream from position –40. Nuclei isolated from these cells synthesize constitutively IFN-ß1 RNA from the partially deleted promoter. The IFN-ß1 RNA synthesized by nuclei of uninduced SR117-21E cells is similar to that made by nuclei of poly(rI):(rC)-induced cells, but does not accumulate and hence no IFN is produced unless the cells have been treated either by ds RNA or by cycloheximide. We conclude that the IFN-ß1 gene has, in addition to the transcription control due to upstream promoter sequences, an additional post-transcriptional control acting on mRNA accumulation and linked to sequences close to the TATA box and RNA start site. Both controls are relieved by ds RNA.


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