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Nucleic Acids Research, 1984, Vol. 12, No. 18 7199-7213
© 1984

MOLECULAR BIOLOGY

Correlation between suppressed meiotic recombination and the lack of DNA strand-breaks in the rRNA genes of Saccharomyces cerevisiae

Anders Høgset and Tordis B. Øyen

Department of Biochemistry, University of Oslo P.O.Box 1041, Blindern, Oslo 3, Norway

Received July 24, 1984. Revised September 7, 1984. Accepted September 7, 1984.

We have examined wether the suppressed homologous meiotic recombination within the rDNA of S. cerevisiae is reflected by a lack of possibly recombination-initiating strand-breaks in this part of the genome. Our findings indicate that bulk DNA in the ds-break repair deficient mutant rad52/rad52 accumulates a limited number of both ss- and ds-breaks during meiosis as compared to a RAD+/rad52 heterozygote. The rDNA-containing chromosome is however protected against these breaks, and thus this may be an explanation for the suppression of recombination in the rDNA. The fact that ds-breaks seem to be involved gives indirect support to the ds-break-repair model for recombination.


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[Abstract] [Full Text]


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