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Nucleic Acids Research, 1984, Vol. 12, No. 19 7467-7478
© 1984

MOLECULAR BIOLOGY

Aminoacyl RNA domain of turnip yellow mosaic virus Val-RNA interacting with elongation factor Tu

Rajiv L. Joshi+,*, Heinz Faulhammer*, François Chapeville+, Mathias Sprinzl* and Anne-Lise Haenni+

+Institut Jacques Monod, CNRS and Université Paris VII 2 Place Jussieu, 75251 Paris Cedex 05, France *Lehrstuhl für Biochemie der Universität Bayreuth Postfach 3008, 8580 Bayreuth, FRG

Received August 15, 1984. Accepted September 12, 1984.

Turnip yellow mosaic virus(TYMV) Val-RNA forms a complex with the pep-tide elongation factor Tu (EF-Tu) in the presence of GTP: the Val-RNA is protected by EF-Tu.GTP from non-enzymatic deacylation and nuclease digestion. The determination of the length of the shortest TYMV Val-RNA fragment that binds EF-Tu.GTP leads us to conclude that the valylated aminoacyl RNA domain equivalent in tRNAs to the continuous helix formed by the acceptor stem and the T arm is sufficient for complex formation. Since the aminoacyl RNA domain is also sufficient for adenylation by the ATP(CTP):tRNA nucleotidyltransfer-ase, an analogy can be drawn between these two tRNA-specific proteins.


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[Abstract] [Full Text]


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