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Nucleic Acids Research, 1984, Vol. 12, No. 21 8017-8028
© 1984

MOLECULAR BIOLOGY

Kinetoplast DNA minicircles of trypanosomatids encode for a protein product

Joseph Shlomai and Anat Zadok

Kuvin Centre for the Study of Infectious and Tropical Diseases, Hebrew University-Hadassah Medical School Jerusalem 91010, Israel

Received August 14, 1984. Revised October 8, 1984. Accepted October 8, 1984.

The major constituent of the trypanosomal kinetoplast ONA network are several thousand duplex DNA minicircles whose biological function is still unknown. The coding capacity and expression of these DNA minicricles, was studied in the trypanosomatid Crithidia fasciculata. Kinetoplast DNA minicircle fragments inserted into bacterial plasmid vectors were expressed in the bacterial cell. Sera elicited in rabbits, by immunization with the translational products of kinetoplast DNA minicircles in E.coli, reacted specifically with Crithidia fasciculata cellular antigens. It is inferred that kinetoplast DNA minicircles contain long open reading frames of nucleotides which are expressed in the trypanosomatid cell.


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