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Nucleic Acids Research, 1984, Vol. 12, No. 21 8043-8058
© 1984

MOLECULAR BIOLOGY

S1-hypersensitive sites in eukaryotic promoter regions

Todd Evans, Eric Schon, Grazyna Gora-Maslak, Jennifer Patterson and Argiris Efstratiadis

Department of Human Genetics and Development, Columbia University 701 West 168th Street, New York, NY 10032, USA

Received August 8, 1984. Revised October 4, 1984. Accepted October 4, 1984.

We have examined by fine mapping the S1 nuclease-hypersensitivity of the 5' flanking regions of the human ß-globin and rat preproinsulin II genes and of the SV40 origin/enhancer region. In all cases S1-hypersensitive sites are located in known or presumed promoter/regulatory regions. Though a consensus DNA sequence is not evident, all of these sites reside in predominantly homopurine-homopyrimidine stretches. The alternate (non-B) DNA structure which is revealed by the enzymatic probe is a sequence-dependent feature of a short stretch of DNA, which is retained upon transplantation into a foreign environment. The alternate structure exhibits S1-nicking patterns uniquely different from those associated with the presence of Z-DNA.


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