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Nucleic Acids Research, 1984, Vol. 12, No. 23 9095-9110
© 1984

CHEMISTRY

Synthesis of phosphorothloate-contaming DNA fragments by a modified bydroxybenzotriazole phospbotriester approach

J.E. Marugg, C. van den Bergh, M. Tromp, G.A. van der Marel, W.J. van Zoest+ and J.H. van Boom*

Gorlaeus Laboratories PO Box 9502, 2300 RA Leiden +Gist Brocades R&D PO Box 1, 2600 MA Delft, The Netherlands

*To whom correspondnce should be sent

Received October 12, 1984. Revised November 12, 1984. Accepted November 12, 1984.

The phosphorothioylating agent which was obtained by treating 2,5-dichloro-phenyl phosphorodichloridothioate with l-hydroxy-6-nitrobenzotriazole proved to be very effective for the synthesis in solution and on a solid support of phosphorothioate-containing DNA fragments.


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