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Nucleic Acids Research, 1984, Vol. 12, No. 23 9137-9142
© 1984

CHEMISTRY

Filter disc supported oligonucleotide synthesis by the phosphite method

Johann Ott and Fritz Eckstein

Max-Planck-Institut für experimentelle Medizin, Abteilung Chemie, Hermann-Rein-Strasse 3 D-3400 Göttingen, FRG

Received September 25, 1984. Revised November 7, 1984. Accepted November 7, 1984.

The phosphite approach to oligodeoxynucleotide synthesis has been applied to the filter disc support. The method is exemplified here by the preparation of eight decadeoxynucleotides.


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