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Nucleic Acids Research, 1984, Vol. 12, No. 24 9323-9331
© 1984

MOLECULAR BIOLOGY

Organization and structure of the mouse interleukin-2 gene

Akira Fuse*, Takashi Fujita, Hidetaro Yasumitsu, Nobukazu Kashima+, Katsushige Hasegawa and Tadatsugu Taniguchi§

Department of Biochemistry, Cancer Institute, Japanese Foundation for Cancer Research Toshimaku, Tokyo 170, Japan Institute for Molecular and Cellular Biology, Osaka University Suita-shi, Osaka 565, Japan

§To whom correspondence should be addressed

Received October 10, 1984. Accepted November 20, 1984.

We have cloned a chromosomal DNA segment which covers the entire sequence for the murine interleukin-2 gene and analysed the structure of the gene. The coding regions are separated into four blocks by three introns each of which is located similarly to the corresponding human gene. The exon sequences can be aligned perfectly with the previously cloned cDNA sequence. Of particular interests is the presence of sequences within the 5'- flanking region which are highly conserved between mouse and man. The conserved region which spans more than 400 base pairs may play a role in the regulation of IL-2 gene expression.

*Present address: Department of Microbiology, School of Medicine, Chiba University, Chiba 280, Japan

+Present address: Central Research Laboratory, Ajinomoto Co.Inc., Totsuka-ku, Yokohama 244, Japan


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