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Nucleic Acids Research, 1984, Vol. 12, No. 24 9473-9487
© 1984

MOLECULAR BIOLOGY

Complete nucleotide sequence of the murine H-2kk gene. Comparison of three H-2K locus alleles

Bernd Arnold+, Hans-Gerhard Burgert§, Alan L. Archibald§ and Sune Kvist§,*

European Molecular Biology Laboratory Postfach 10.2209, D-6900 Heidelberg, FRG

*To whom correspondence should be addressed

Received November 2, 1984. Revised November 30, 1984. Accepted November 30, 1984.

We have determined the DNA sequence of the H-2Kk gene of the mouse major histocompatibility complex (MHC). Comparison on the nucleotide and protein level of three H-2K alleles (Kk, Kb and Kd) reveals a high degree of homology, in particular between the Kb and Kk alleles. Differences between the two latter antigens are almost exclusively confined to the {alpha}1 and {alpha}2 domains. At nine positions in the extracellular part of the molecules we have found allele-specific amino acids. Interestingly, 78% of these residues are either polar or carry hydroxyl-groups. This makes it likely that they are exposed on the surface of the molecules and might then be part of antigenic determinants. We have also identified potentially allele-specific nucleotide sequences of the K genes which might be used as specific DNA probes.

+Present address: German Cancer Research Center, Im Neuenheimer Feld 280, D-6900 Heidelberg, FRG

§Present address: Swiss Institute for Experimental Cancer Research, Ch. des Boveresses, CH-1066 Epalinges s/Lausanne, Switzerland


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