Nucleic Acids Research, 1984, Vol. 12, No. 6 2823-2836
© 1984
MOLECULAR BIOLOGY |
Methylation patterns of repetitive DNA sequences in germ cells of Mus muscutus
Department of Molecular Biology, Roswell Park Memorial Institute Buffalo, NY 14263 USA MRC Clinical and Population Genetics Unit, Western General Hospital Edinburgh EH4 2XU, UK
*To whom correspondence should be addressed
Received December 5, 1983. Revised February 27, 1984. Accepted February 27, 1984.
The major and the minor satellite sequences of Mus musculus were under-methylated in both sperm and oocyte DNAs relative to the amount of under-methylation observed in adult somatic tissue DNA. This hypomethylation was specific for satellite sequences in sperm DNA. Dispersed repetitive and low copy sequences show a high degree of methylation in sperm DNA; however, a dispersed repetitive sequence was undermethylated in oocyte DNA. This finding suggests a difference in the amount of total genomic DNA methylation between sperm and oocyte DNA. The methylation levels of the minor satellite sequences did not change during spermiogenesis, and were not associated with the onset of meiosis or a specific stage in sperm development
+Present address: Department of Zoology, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, UK
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