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Nucleic Acids Research, 1985, Vol. 13, No. 11 3941-3952
© 1985

Articles

Structure of the human {alpha}1acid glycoprotein gene: sequence homology with other human acute phase protein genes

Luciana Dente, Gennaro Ciliberto and Riccardo Cortese

European Molecular Biology Laboratory Meyerhofstrasse 1, 6900 Heidelberg, FRG and Istituto di Scienze Biochimiche, University of Naples Naples, Italy

Address any correspondence to EMBL

Received March 11, 1985. Revised May 7, 1985. Accepted May 7, 1985.

We have determined the sequence coding for human {alpha}1-acid glycoprotein from two independently isolated cDNA clones and a genomic clone. The aminoacid sequences deduced from the three clones, deriving from three different individuals, are identical. Southern blot analysis on human DNA indicates that there are at least two genes coding for {alpha}1AGP. We propose that {alpha}1AGP found in plasma is a mixture of the products of these two different genes. This is the simpler explanation for the heterogeneity in the aminoacid composition in purified {alpha}1AGP observed by Schmid et al. (1). DNA sequence comparison with cDNA clones coding for human {alpha}1antitrypsin and haptoglobin shows a conserved sequence within the 5' untranslated region which may play a role in the acute phase response


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