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Nucleic Acids Research, 1985, Vol. 13, No. 11 4029-4045
© 1985

Articles

The ribosomal RNA genes of Drosophila mitochondrial DNA

Douglas O. Clary* and David R. Wolstenholme

Department of Biology, University of Utah Salt Lake City, UT 84112, USA

Received February 20, 1985. Revised May 2, 1985. Accepted May 2, 1985.

The nucleotide sequence of a segment of the mtDNA molecule of Drosophila yakuba which contains the A+T-rich region and the small and large rRNA genes separated by the tRNAval gene has been determined. The 5 end of the small rRNA gene was located by Sl protection analysis. In contrast to mammalian mtDNA, a tRNA gene was not found at the 5' end of the D. yakuba small rRNA gene. The small and large rRNA genes are 20.7% and 16.7% G+C and contain only 789 and 1326 nucleotides. The 5' regions of the small rRNA gene (371 nucleotldes) and of the large rRNA gene (643 nucleotidea) are extremely low in G+C (14.6% and 9.5%, respectively) and convincing sequence homologies between these regions and the corresponding regions of mouse mt-rRNA genes were found only for a few short segments. Nevertheless, the entire lengths of both of the D. yakuba mt-rRNA genes can be folded into secondary structures which are remarkably similar to secondary structures proposed for the rRNAs of mouse mtDNA. The replication origin-containing, A+T-rich region (1077 nucleotides; 92.8% A+T), which lies between the tRNAile gene and the small rRNA gene, lacks open reading frames greater than 123 nucleotides.

*Present address: Department of Biochemistry, Stanford Scholl of Medicine, standford, CA 94305, U.S.A.


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