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Nucleic Acids Research, 1985, Vol. 13, No. 12 4379-4400
© 1985

Articles

Structure and expression of the M2 genomic segment of a type 2 killer virus of yeast

Ernest M. Hannig and Michael J. Leibowitz

Department of Microbiology, University of Medicine and Dentistry of New Jersey, Rutgers Medical School P.O. Box 101, Piscataway, NJ 08854, USA

Received February 21, 1985. Revised May 23, 1985. Accepted May 23, 1985.

The M2 double-stranded (da) RNA apeciea encodes toxin and resistance functions in Saccharomyces cereviaiae straina with the K2 killer specificity. RNA sequence analysis reveals the presence of a large open reading frame on the larger heat-cleavage product of M2 dsRNA, which is translated in vitro to yield a 28 kd polypeptide as a major product. The postulated translation initiator AUG triplet is located within a stem and loop structure near the 5'terminus of the positive strand, which also contains plausible 16S and 5.8S ribosomal RNA binding sites. These features nay serve to regulate the translation of the K2 toxin precursor. The M1 (from type 1 yeast killers) and M2 dsRNA species lack extensive sequence homology, although specific features are shared, which may represent structural elements required for gene expression and replication


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