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Nucleic Acids Research, 1985, Vol. 13, No. 12 4597-4608
© 1985

Articles

The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization

Karl J. Lackner*, Simon W. Law and H. Bryan Brewer, Jr.

Molecular Disease Branch, National Heart, Lung and Blood Institute, National Institutes of Health Bethesda, MD 20205, USA

*Address all correspondence to: Dr. Karl J. Lackner, Bldg. 10, Room 7N117, National Institutes of Health, Bethesda, MD 20205, USA

Received February 25, 1985. Revised May 9, 1985. Accepted May 10, 1985.

The gene for human apolipoprotein (apo) A-II has been isolated from a human genomic DNA library. The cloned fragment was approximately 14 kilobase-pair (kb) long, and extended about 9.0 kb upstream as well as 3.5 kb downstream from the apoA-II gene, which was contained within a 3.1 kb Hind III fragment of human DNA. The complete nucleic acid sequence of the apoA-II gene has been determined, establishing that the apoA-II gene is interrupted by three intervening sequences of 182, 293, and 395 bp. The second intron is of particular Interest, because It contains a 33 bp sequence of alternating G and T residues very close to the 3' splice site which has the potential to form a left handed Z-helix structure In vivo. A restriction fragment length polymorphism 3'from the apoA-II gene has been detected which may serve as a marker for the long arm of chromosome 1 in linkage analyses


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