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Nucleic Acids Research, 1985, Vol. 13, No. 2 381-387
© 1985

Articles

Chromosomal orientation of the lambda light chain locus: V{lambda} is proximal to C{lambda} in 22q11

B.S. Emanuel1, L.A. Cannizzaro1,2, I. Magrath3, Y. Tsujimoto4, P.C. Nowell1 and C.M. Croce4,*

1Depts. Pediatrics, Human Genetics, Pathology and Laboratory Medicine, Univ. Pennsylvania Sch. Med. Philadelphia, PA 19104 3National Cancer Inst., Pediatric Branch Bethesda, MD 20205 4The Wistar Inst. Anatomy and Biology 36 Spruce Street, Philadelphia, PA 19104, USA

+To whom reprint requests should be sent

Received October 29, 1984. Accepted December 19, 1984.

We have demonstrated that the chromosomal breakpoint at 22q11 of a Burkitt lymphoma cell line (PA682) with an 8;22 translocation interrupts the variable region of the lambda light chain locus. In these cells, all of the C{lambda} and some V{lambda} sequences translocate to the 8q+ chromosome whereas some V{lambda} sequences remain on the 22q–. These results indicate that the lambda light chain locus on the long arm of chromosome 22 is oriented such that V{lambda} is proximal to C{lambda}.

2Present address: Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University College of Medicine, P.O. Box 850, Hershey, PA 17033, USA


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