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Nucleic Acids Research, 1985, Vol. 13, No. 24 8827-8841
© 1985

Articles

Structure of the human gene encoding the invariant {gamma}-chain of class II histocompatibility antigens

Jiro Kudo, Lian-Yu Chao, Franco Narni and Grady F. Saunders

Department of Biochemistry and Molecular Biology, University of Texas, M.D. Anderson Hospital and Tumor Institute 6723 Bermer Avenue, Houston, TX 77030, USA

Received August 12, 1985. Revised November 13, 1985. Accepted November 13, 1985.

The primary structures of a cDNA and the genomic DNA of a gene selectively expressed in chronic lymphocytic leukemia were determined. A computer search of the nucleotide sequence data bank identified this gene as the invariant {gamma}-chain associated with class II histoeompatibility antigens. The invariant {gamma}-chain genomic sequence spans about 11 kilobases, with eight exons and seven introns. Three of the introns contain members of the Alu repeat family. A putative cap site and promoter sequence were identified at the 5' end of the gene. One or two copies of the gene is present in each haploid genome, and no evidence for amplification or polymorphism was obtained.


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