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Nucleic Acids Research, 1985, Vol. 13, No. 24 8883-8886
© 1985

Articles

A processed pseudogene in an intron of the HLA-DPß1 chain gene is a member of the ribosomal protein L32 gene family

John A.T. Young and John Trowsdale

Imperial Cancer Research Fund 44 Lincoln's Inn Fields, London WC2A 3PX, UK

Received October 24, 1985. Accepted November 21, 1985.

A sequence in an intron of the human HLA-DPß1 gene was identified by its homology to the gene encoding ribosomal protein L32 (rpL32). It lacked introns indicating that it was derived from a processed rpL32 mRNA transcript. A human cDNA clone encoding rpL32 was isolated and compared to this human pseudogene and to several related mouse sequences, one of which is contained in an intron of the murine dihydrofolate reductase gene. Comparison of these sequences revealed that they were more related within species than between, suggesting that they became inserted in the genome after man and mouse diverged.


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