Nucleic Acids Research, 1985, Vol. 13, No. 3 805-823
© 1985
Articles |
Characterization of a mouse interferon gene locus I. Isolation of a cluster of four 
-interferon genes
Oncology Center 1-109. Johns Hopkins University School of Medicine 600 North Wolfe St., Baltimore, MD 21205, USA
*To whom correspondence should be addressed
Received November 20, 1984. Revised January 9, 1985. Accepted January 9, 1985.
A BALB/c mouse genoinic library was screened with a murine interferon 
2 (MuIFN-2 cDNA coding region fragment. Eight clones were isolated which contain different mouse chromosomal segments related to the MuIFN-2 probe and a 28 kilobase (kb) region of mouse genomic DNA containing four different MuIFN- genes (1, 4, 5 and 6 was identified characterized; an intergenic 1000 nucleotide long conserved sequence was found to be associated with three of these four a genes, indicating that this -IFN gene cluster evolved through tandem duplications. Sequence analysis revealed the absence of a polyadenylation site in the 3' untranslated region of MuIFN-1 and showed that one of the genes (4) contains an internal deletion of 5 amino acids in the coding region.
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