Skip Navigation

This Article
Right arrow Print PDF (2714K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (98)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Small, D.
Right arrow Articles by Vogelstein, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Small, D.
Right arrow Articles by Vogelstein, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1985, Vol. 13, No. 7 2413-2431
© 1985

Articles

The association of transcribed genes with the nuclear matrix of Drosophila cells during heat shock

Donald Small, Barry Nelkin and Bert Vogelstein*

Cell Structure and Function Laboratory, Oncology Center, Johns Hopkins University School of Medicine Baltimore, MD 21205, USA

*To whom correspondence should be addressed

Received November 21, 1984. Revised March 11, 1985. Accepted March 11, 1985.

Using the transcriptionai modulation afforded by heat shock, we found that the association of active genes with the nuclear matrix was not dependent on their level of transcription. Heat shock genes were matrix associated both before heat shock (when transcription was relatively low), and during heat shock (when transcription was greatly increased). Conversely, the cytoplasmlc actin gene was matrix associated during normal growth conditions (when transcription was high) and during heat shock (when transcription was greatly decreased). Removal of greater than 99.7% of nascent RNA during preparation of the matrices did not affect these findings. Detailed examination of the cytoplasmlc actin gene revealed that its matrix association was apparently mediated by multiple interactions near the 5' end of the gene.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
Y. Onishi, S. Hanai, T. Ohno, Y. Hara, and N. Ishida
Rhythmic SAF-A Binding Underlies Circadian Transcription of the Bmal1 Gene
Mol. Cell. Biol., May 15, 2008; 28(10): 3477 - 3488.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J.-h. Tan, J. C. Wooley, and W. M. LeStourgeon
Nuclear Matrix-like Filaments and Fibrogranular Complexes Form through the Rearrangement of Specific Nuclear Ribonucleoproteins
Mol. Biol. Cell, May 1, 2000; 11(5): 1547 - 1554.
[Abstract] [Full Text]

Home page
 Genes Dev.Home page
D C Amberg, A L Goldstein, and C N Cole
Isolation and characterization of RAT1: an essential gene of Saccharomyces cerevisiae required for the efficient nucleocytoplasmic trafficking of mRNA.
Genes & Dev., July 1, 1992; 6(7): 1173 - 1189.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
J Schaack, W Y Ho, P Freimuth, and T Shenk
Adenovirus terminal protein mediates both nuclear matrix association and efficient transcription of adenovirus DNA.
Genes & Dev., July 1, 1990; 4(7): 1197 - 1208.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.