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Nucleic Acids Research, 1985, Vol. 13, No. 7 2545-2558
© 1985

Articles

Nucleotide sequence of the 3' exon of the human N-myc gene

Richard W. Michitsch and Peter W. Melera

Memorial Sloan-Kettering Cancer Center, Graduate Program in Molecular Biology and Virology 1275 York Avenue, New York, NY 10021, USA

Received December 28, 1984. Revised March 11, 1985. Accepted March 11, 1985.

We have analyzed a 3.8 kb Eco RI fragment of genonric DNA obtained from the amplified N-myc gene of human neuroblastoma cell line BE(2)-C. This fragment contains an exon with an open reading frame encoding approximately 170 amino acids of the carboxy-terminal end of the putative N-myc protein. Comparison of the inferred amino acid sequence of this peptide with that of the 3' domain of the human c-myc protein shows that locally conserved but dispersed regions of homology exist throughout the lengths of these peptides, while hydropathy plots indicate that the physical properties implied by their primary sequences are strikingly similar. Based upon these and other considerations, it is sugggested that the 3' domains of c-myc and N-myc may potentially share related functions.


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