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Nucleic Acids Research, 1985, Vol. 13, No. 8 3005-3014
© 1985

Articles

A mitochondrial reading frame which may code for a maturase-like protein in Saccharomyces cerevisiae

Bertrand Séraphin, Michel Simon and Gérard Faye

Institut Curie, Section de Biologie Bâtiment 110, Centre Universitaire, 91405-Orsay, France

Received January 26, 1985. Revised March 18, 1985. Accepted March 18, 1985.

In S. cerevisiae, the large oxi3/oli2 mitochondrial transcript contains the products of the oxi3, aapl and oli2 genes and an unassigned reading frame, RF3. In the work presented here, we have completed the nucleotide sequence of RF3. We have shown that RF3 is composed of four fairly large ORFs which overlap within GC rich sequences. Furthermore, a shift of +1 base was found between each pair of consecutive reading frames. We discuss how these frameshifts could be removed to produce a 500 aminoacid long protein containing the two well conserved P1 and P2 oligopeptide sequences featuring several mitochondrial intron reading frames, suggesting, thereby, a RNA-maturase-like activity for the putative RF3 protein. In addition, we suggest that the insertion of GC clusters in a gene could provide a novel way of regulating its expression.


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