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Nucleic Acids Research, 1985, Vol. 13, No. 9 3221-3239
© 1985

Articles

In vivo transcription of rDNA spacers in Drosophila

Vicki L. Murtif* and Peter M.M. Rae+

Department of Biology, Yale University New Haven, CT 06511, USA

Received February 4, 1985. Revised April 11, 1985. Accepted April 12, 1985.

The sequence-nonhomologous rDNA spacers of D. melanogaster and D. virilis exhibit remarkably similar organizations and transcription capabilities. In spacers of both species, tandemly repeated sequences are present upstream of the beginning of the pre-rRNA coding region, and the repeats are capable of transcriptional activity. Short, nuclear transcripts homologous to the spacer repeats have been identified by Si nuclease protection experiments and by northern blot analyses. Although spacer transcripts are rare in steady state RNA populations, the presence of multiple promoter elements may suggest a regulatory role for rDNA spacers.

*Present address: Case Western Reserve University, School of Medicine, Department of Biochemistiy, Cleveland, OH 44106, USA

+Present address: Molecular Diagnostics, Inc., 400 Morgan Lane, West Haven, CT 06516, USA


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