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Nucleic Acids Research, 1988, Vol. 16, No. 12 5491-5502
© 1988

Articles

Structure of the bovine pancreatic ribonuclease gene: the unique intervening sequence in the 5' untranslated region contains a promoter-like element

A. Carsana, E. Confalone, M. Palmieri, M. Libonati1 and A. Furia*

Dipartimento di Chimica Organica e Biologica, Universitá di Napoli Via Mezzocannone 16, 80134 Napoli, Italy 1Istituto di Chimica Biologica, Universitá di Verona Strada Le Grazie, 37134 Verona, Italy

*To whom correspondence should be addressed

Received February 5, 1988. Revised April 13, 1988. Accepted April 13, 1988.

Although pancreatic ribonucleases are extensively studied proteins, little information is available on nucleic acids coding for these enzymes. Here, for the first time, the structure of a gene coding for such an enzyme, the well known bovine pancreatic ribonuclease, is reported. The coding region of this gene is devoid of introns, whereas the 5' untranslated sequence of the pancreatic transcript contains an intron of 735 nucleotides. This intervening sequence is endowed with signals (CAAT and TATA boxes) which might act as regulatory elements. The structural organization of this gene suggests that the sequence coding for the bovine pancreatic ribonuclease might be expressed under the control of two different promoters.


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