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Nucleic Acids Research, 1988, Vol. 16, No. 13 5991-5998
© 1988

Articles

Sequence identity between an inverted repeat family of transposable elements in Drosophila and Caenorhabditis

L. J. Harris, D. L. Baillie1 and A. M. Rose

Department of Medical Genetics, University of British Columbia Vancouver, BC V6T 1W5, Canada 1Department of Biological Sciences, Simon Fraser University Burnaby, BC V5A 1S6, Canada

Received February 26, 1988. Revised May 31, 1988. Accepted May 31, 1988.

The Tc1-like transposable elements, originally described in Caenorhabditis elegans1,2, have a much wider phylogenetic distribution than previously thought. In this paper, we demonstrate that Tc1 shares sequence identity in its open reading frame and terminal repeats with a new transposable element Barney (also known as TCb1-Transposon Caenorhabditis briggsae 1). Barney was detected and isolated by Tc1 hybridization from the closely related nematode species, Caenorhabditis briggsae. The conserved open reading frames of Tc1 and Barney share identity with a structurally similar family of elements named HB found in Drosophila melanogaster, after the introduction of 3 small centrally located deletions in HB1. These reading frames would code for proteins with 30% amino acid identity (42% when conservative changes are included). Tc1, Barney and HB1 contain highly conserved blocks of amino acids which are likely to be in the functional domains of the putative transposase.


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