Skip Navigation

This Article
Right arrow Print PDF (1684K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (40)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Neuer-Nitsche, B.
Right arrow Articles by Werner, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Neuer-Nitsche, B.
Right arrow Articles by Werner, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1988, Vol. 16, No. 17 8351-8360
© 1988

Articles

Functional role of a highly repetitive DNA sequence in anchorage of the mouse genome

Beatrice Neuer-Nitsche, Xiang Lu and Dieter Werner

Institut für Zell- und Tumorbiologie, Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280, D-6900 Heidelberg, FRG

Received June 24, 1988. Revised August 15, 1988. Accepted August 15, 1988.

The major portion of the eukaryotic genome consists of various categories of repetitive DNA sequences which have been studied with respect to their base compositions, organizations, copy numbers, transcription and species specificities [1]; their biological roles, however, are still unclear. A novel quality of a highly repetitive mouse DNA sequence is described which points to a functional role: All copies (approximately 50,000 per haploid genome) of this DNA sequence reside on genomic AIu I DNA fragments each associated with nuclear polypeptides that are not released from DNA by proteinase K, SDS and phenol extraction. By this quality the repetitive DNA sequence is classified as a member of the sub-set of DNA sequences involved in tight DNA-polypeptide complexes wich have been previously shown to be components of the subnuclear structure termed ‘nuclear matrix’ [2, 3, 4]. From these results it has to be concluded that the repetitive DNA sequence characterized in this report represents or comprizes a signal for a large number of site specific attachment points of the mouse genome in the nuclear matrix.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
G. Schilders, E. van Dijk, and G. J.M. Pruijn
C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing
Nucleic Acids Res., April 4, 2007; (2007) gkm082v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
T. Erdemir, B. Bilican, D. Oncel, C. R. Goding, and U. Yavuzer
DNA damage-dependent interaction of the nuclear matrix protein C1D with translin-associated factor X (TRAX)
J. Cell Sci., January 1, 2002; 115(1): 207 - 216.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
K Rothbarth, E Spiess, B Juodka, U Yavuzer, P Nehls, H Stammer, and D Werner
Induction of apoptosis by overexpression of the DNA-binding and DNA-PK-activating protein C1D
J. Cell Sci., January 7, 1999; 112(13): 2223 - 2232.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
U. Yavuzer, G. C.M. Smith, T. Bliss, D. Werner, and S. P. Jackson
DNA end-independent activation of DNA-PK mediated via association with the DNA-binding protein C1D
Genes & Dev., July 15, 1998; 12(14): 2188 - 2199.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.