Nucleic Acids Research, 1988, Vol. 16, No. 20 9687-9705
© 1988
Articles |
Empirical estimation of protein-induced DNA bending angles: applications to 
site-specific recombination complexes
Division of Biology and Medicine, Brown University Providence, RI 02912, USA
*To whom correspondence should be addressed
Received June 9, 1988. Accepted September 15, 1988.
Protein-induced DNA bending is an important element in the structure of many protein-DNA complexes, including those involved in replication, transcription, and recombination. To understand these structures, the path followed by the DNA in each complex must be established. We have generated an empirical relation between the degree of bending and the altered electrophoretic mobility in polyacrylamide gels that allows estimation of protein-induced bends. This technique has been used to analyze 17 different protein-DNA complexes formed by six proteins including the four proteins involved in lambda site-specific recombination. The simplicity of this technique should make it useful in estimating angles for the construction of models of protein-DNA complexes and readily applicable to many systems where questions of higher-order structure are important for understanding function.
+Present address: Department of Molecular Genetics, Pfizer Central Research, Groton, CT 06340, USA
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. Takiya, S. Saito, T. Yokoyama, D. Matsumoto, T. Aizawa, M. Kamiya, M. Demura, and K. Kawano DNA-Binding Property of the Novel DNA-Binding Domain STPR in FMBP-1 of the Silkworm Bombyx mori J. Biochem., July 1, 2009; 146(1): 103 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Mruk and R. M. Blumenthal Tuning the relative affinities for activating and repressing operators of a temporally regulated restriction-modification system Nucleic Acids Res., February 1, 2009; 37(3): 983 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-Y. Bouet and D. Lane Molecular Basis of the Supercoil Deficit Induced by the Mini-F Plasmid Partition Complex J. Biol. Chem., January 2, 2009; 284(1): 165 - 173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. F. Browning, J. A. Cole, and S. J. W. Busby Regulation by Nucleoid-Associated Proteins at the Escherichia coli nir Operon Promoter J. Bacteriol., November 1, 2008; 190(21): 7258 - 7267. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Pul, B. Lux, R. Wurm, and R. Wagner Effect of upstream curvature and transcription factors H-NS and LRP on the efficiency of Escherichia coli rRNA promoters P1 and P2 - a phasing analysis Microbiology, September 1, 2008; 154(9): 2546 - 2558. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Mattis, R. I. Gumport, and J. F. Gardner Purification and Characterization of Bacteriophage P22 Xis Protein J. Bacteriol., September 1, 2008; 190(17): 5781 - 5796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Stonehouse, G. Kovacikova, R. K. Taylor, and K. Skorupski Integration Host Factor Positively Regulates Virulence Gene Expression in Vibrio cholerae J. Bacteriol., July 1, 2008; 190(13): 4736 - 4748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hazelbaker, M. A. Azaro, and A. Landy A Biotin Interference Assay Highlights Two Different Asymmetric Interaction Profiles for {lambda} Integrase Arm-type Binding Sites in Integrative Versus Excisive Recombination J. Biol. Chem., May 2, 2008; 283(18): 12402 - 12414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Flanigan and J. F. Gardner Interaction of the Gifsy-1 Xis Protein with the Gifsy-1 attP Sequence J. Bacteriol., September 1, 2007; 189(17): 6303 - 6311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pluciennik and P. Modrich From the Cover: Protein roadblocks and helix discontinuities are barriers to the initiation of mismatch repair PNAS, July 31, 2007; 104(31): 12709 - 12713. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Papapanagiotou, S. D. Streeter, P. D. Cary, and G. G. Kneale DNA structural deformations in the interaction of the controller protein C.AhdI with its operator sequence Nucleic Acids Res., April 10, 2007; (2007) gkm129v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Ruiz-Maso, R. Lurz, M. Espinosa, and G. del Solar Interactions between the RepB initiator protein of plasmid pMV158 and two distant DNA regions within the origin of replication Nucleic Acids Res., February 28, 2007; 35(4): 1230 - 1244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Abbani, C. V. Papagiannis, M. D. Sam, D. Cascio, R. C. Johnson, and R. T. Clubb Structure of the cooperative Xis-DNA complex reveals a micronucleoprotein filament that regulates phage lambda intasome assembly PNAS, February 13, 2007; 104(7): 2109 - 2114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Wang, S. E. Lindner, E. R. Leight, and B. Sugden Essential Elements of a Licensed, Mammalian Plasmid Origin of DNA Synthesis Mol. Cell. Biol., February 1, 2006; 26(3): 1124 - 1134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Rosario and R. A. Bender Importance of Tetramer Formation by the Nitrogen Assimilation Control Protein for Strong Repression of Glutamate Dehydrogenase Formation in Klebsiella pneumoniae J. Bacteriol., December 15, 2005; 187(24): 8291 - 8299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L.-Y. Wong and A. C. Wilson Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces a Strong Bend on Binding to Terminal Repeat DNA J. Virol., November 1, 2005; 79(21): 13829 - 13836. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Abraham and A. K. Vershon N-Terminal Arm of Mcm1 Is Required for Transcription of a Subset of Genes Involved in Maintenance of the Cell Wall Eukaryot. Cell, November 1, 2005; 4(11): 1808 - 1819. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lahooti, P. L. Roesch, and I. C. Blomfield Modulation of the Sensitivity of FimB Recombination to Branched-Chain Amino Acids and Alanine in Escherichia coli K-12 J. Bacteriol., September 15, 2005; 187(18): 6273 - 6280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Stellwagen, Y. Lu, and N. C. Stellwagen Curved DNA molecules migrate anomalously slowly in free solution Nucleic Acids Res., August 5, 2005; 33(14): 4425 - 4432. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-C. Chen, J. Feng, B.-H. Hou, F.-Q. Li, Q. Li, and G.-F. Hong Modulating DNA bending affects NodD-mediated transcriptional control in Rhizobium leguminosarum Nucleic Acids Res., May 4, 2005; 33(8): 2540 - 2548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Dame, J. van Mameren, M. S. Luijsterburg, M. E. Mysiak, A. Janicijevic, G. Pazdzior, P. C. van der Vliet, C. Wyman, and G. J.L. Wuite Analysis of scanning force microscopy images of protein-induced DNA bending using simulations Nucleic Acids Res., April 20, 2005; 33(7): e68 - e68. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Radman-Livaja, T. Biswas, D. Mierke, and A. Landy Inaugural Article: Architecture of recombination intermediates visualized by in-gel FRET of {lambda} integrase-Holliday junction-arm DNA complexes PNAS, March 15, 2005; 102(11): 3913 - 3920. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Muir and J. W. Gober Role of Integration Host Factor in the Transcriptional Activation of Flagellar Gene Expression in Caulobacter crescentus J. Bacteriol., February 1, 2005; 187(3): 949 - 960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Pérez-Lago, M. Salas, and A. Camacho A precise DNA bend angle is essential for the function of the phage {phi}29 transcriptional regulator Nucleic Acids Res., January 7, 2005; 33(1): 126 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Whitworth, S. J. Bryan, A. E. Berry, S. J. McGowan, and D. A. Hodgson Genetic Dissection of the Light-Inducible carQRS Promoter Region of Myxococcus xanthus J. Bacteriol., December 1, 2004; 186(23): 7836 - 7846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Poore and H. L. T. Mobley Differential regulation of the Proteus mirabilis urease gene cluster by UreR and H-NS Microbiology, December 1, 2003; 149(12): 3383 - 3394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. N. Hengen, I. G. Lyakhov, L. E. Stewart, and T. D. Schneider Molecular flip-flops formed by overlapping Fis sites Nucleic Acids Res., November 15, 2003; 31(22): 6663 - 6673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Saleem, S. Banerjee-Basu, F. B. Berry, A. D. Baxevanis, and M. A. Walter Structural and functional analyses of disease-causing missense mutations in the forkhead domain of FOXC1 Hum. Mol. Genet., November 15, 2003; 12(22): 2993 - 3005. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Kruger and M. Filutowicz {pi} Protein- and ATP-dependent transitions from 'closed' to 'open' complexes at the {gamma} ori of plasmid R6K Nucleic Acids Res., October 15, 2003; 31(20): 5993 - 6003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Tang and S. E. Perry Binding Site Selection for the Plant MADS Domain Protein AGL15: AN IN VITRO AND IN VIVO STUDY J. Biol. Chem., July 18, 2003; 278(30): 28154 - 28159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Warren, M. D. Sam, K. Manley, D. Sarkar, S. Y. Lee, M. Abbani, J. M. Wojciak, R. T. Clubb, and A. Landy Identification of the {lambda} integrase surface that interacts with Xis reveals a residue that is also critical for Int dimer formation PNAS, July 8, 2003; 100(14): 8176 - 8181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Feng, Q. Li, H.-L. Hu, X.-C. Chen, and G.-F. Hong Inactivation of the nod box distal half-site allows tetrameric NodD to activate nodA transcription in an inducer-independent manner Nucleic Acids Res., June 15, 2003; 31(12): 3143 - 3156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. R. Harley, S. Layfield, C. L. Mitchell, J. K. Forwood, A. P. John, L. J. Briggs, S. G. McDowall, and D. A. Jans Defective importin {beta} recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations PNAS, June 10, 2003; 100(12): 7045 - 7050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Angermayr, U. Oechsner, and W. Bandlow Reb1p-dependent DNA Bending Effects Nucleosome Positioning and Constitutive Transcription at the Yeast Profilin Promoter J. Biol. Chem., May 9, 2003; 278(20): 17918 - 17926. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Schaal, W. G. Mallet, D. L. McMinn, N. V. Nguyen, M. M. Sopko, S. John, and B. S. Parekh Inhibition of human papilloma virus E2 DNA binding protein by covalently linked polyamides Nucleic Acids Res., February 15, 2003; 31(4): 1282 - 1291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F.-L. Lim, A. Hayes, A. G. West, A. Pic-Taylor, Z. Darieva, B. A. Morgan, S. G. Oliver, and A. D. Sharrocks Mcm1p-Induced DNA Bending Regulates the Formation of Ternary Transcription Factor Complexes Mol. Cell. Biol., January 15, 2003; 23(2): 450 - 461. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Horii, H. Nagasawa, and J. Nakayama Functional Analysis of TraA, the Sex Pheromone Receptor Encoded by pPD1, in a Promoter Region Essential for the Mating Response in Enterococcus faecalis J. Bacteriol., November 15, 2002; 184(22): 6343 - 6350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Angermayr, U. Oechsner, K. Gregor, G. P. Schroth, and W. Bandlow Transcription initiation in vivo without classical transactivators: DNA kinks flanking the core promoter of the housekeeping yeast adenylate kinase gene, AKY2, position nucleosomes and constitutively activate transcription Nucleic Acids Res., October 1, 2002; 30(19): 4199 - 4207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kita, J. Tsuda, and S.-y. Nakai C.EcoO109I, a regulatory protein for production of EcoO109I restriction endonuclease, specifically binds to and bends DNA upstream of its translational start site Nucleic Acids Res., August 15, 2002; 30(16): 3558 - 3565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Hardwidge, J. M. Zimmerman, and L. J. Maher III Charge neutralization and DNA bending by the Escherichia coli catabolite activator protein Nucleic Acids Res., May 1, 2002; 30(9): 1879 - 1885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Connolly, M. Iwahara, and R. T. Clubb Xis Protein Binding to the Left Arm Stimulates Excision of Conjugative Transposon Tn916 J. Bacteriol., April 15, 2002; 184(8): 2088 - 2099. [Abstract] [Full Text]
|
|
|
|
|
|
R. Popp, T. Kohl, P. Patz, G. Trautwein, and U. Gerischer Differential DNA Binding of Transcriptional Regulator PcaU from Acinetobacter sp. Strain ADP1 J. Bacteriol., April 1, 2002; 184(7): 1988 - 1997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Schultz, M. A. Loven, V. M. S. Melvin, D. P. Edwards, and A. M. Nardulli Differential Modulation of DNA Conformation by Estrogen Receptors alpha and beta J. Biol. Chem., March 1, 2002; 277(10): 8702 - 8707. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Schneider Strong minor groove base conservation in sequence logos implies DNA distortion or base flipping during replication and transcription initiation Nucleic Acids Res., December 1, 2001; 29(23): 4881 - 4891. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Bashaw and J. L. Yates Replication from oriP of Epstein-Barr Virus Requires Exact Spacing of Two Bound Dimers of EBNA1 Which Bend DNA J. Virol., November 15, 2001; 75(22): 10603 - 10611. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. Cho, R. Alcaraz Jr., R. I. Gumport, and J. F. Gardner Characterization of Bacteriophage Lambda Excisionase Mutants Defective in DNA Binding J. Bacteriol., October 15, 2000; 182(20): 5807 - 5812. [Abstract] [Full Text]
|
|
|
|
|
|
C. Beloin, R. Exley, A.-L. Mahé, M. Zouine, S. Cubasch, and F. Le Hégarat Characterization of LrpC DNA-Binding Properties and Regulation of Bacillus subtilis lrpC Gene Expression J. Bacteriol., August 15, 2000; 182(16): 4414 - 4424. [Abstract] [Full Text]
|
|
|
|
|
|
T. Rasko, C. Finta, and A. Kiss DNA bending induced by DNA (cytosine-5) methyltransferases Nucleic Acids Res., August 15, 2000; 28(16): 3083 - 3091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Hanakahi and N. Maizels Transcriptional activation by LR1 at the E{micro} enhancer and switch region sites Nucleic Acids Res., July 15, 2000; 28(14): 2651 - 2657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Drew, D. C. Tang, P. E. Berg, and G. P. Rodgers The role of trans-acting factors and DNA-bending in the silencing of human {beta}-globin gene expression Nucleic Acids Res., July 15, 2000; 28(14): 2823 - 2830. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Acton, J. Mead, A. M. Steiner, and A. K. Vershon Scanning Mutagenesis of Mcm1: Residues Required for DNA Binding, DNA Bending, and Transcriptional Activation by a MADS-Box Protein Mol. Cell. Biol., January 1, 2000; 20(1): 1 - 11. [Abstract] [Full Text]
|
|
|
|
|
|
J. A. Surtees and B. E. Funnell P1 ParB Domain Structure Includes Two Independent Multimerization Domains J. Bacteriol., October 1, 1999; 181(19): 5898 - 5908. [Abstract] [Full Text]
|
|
|
|
|
|
V. Aidinis, T. Bonaldi, M. Beltrame, S. Santagata, M. E. Bianchi, and E. Spanopoulou The RAG1 Homeodomain Recruits HMG1 and HMG2 To Facilitate Recombination Signal Sequence Binding and To Enhance the Intrinsic DNA-Bending Activity of RAG1-RAG2 Mol. Cell. Biol., October 1, 1999; 19(10): 6532 - 6542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. McDowall, A. Argentaro, S. Ranganathan, P. Weller, S. Mertin, S. Mansour, J. Tolmie, and V. Harley Functional and Structural Studies of Wild Type SOX9 and Mutations Causing Campomelic Dysplasia J. Biol. Chem., August 20, 1999; 274(34): 24023 - 24030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Fujiwara, C. Masutani, T. Mizukoshi, J. Kondo, F. Hanaoka, and S. Iwai Characterization of DNA Recognition by the Human UV-damaged DNA-binding Protein J. Biol. Chem., July 9, 1999; 274(28): 20027 - 20033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Blaise, J. Grober, P. Rouet, G. Tavernier, D. Daegelen, and D. Langin Testis Expression of Hormone-sensitive Lipase Is Conferred by a Specific Promoter That Contains Four Regions Binding Testicular Nuclear Proteins J. Biol. Chem., April 2, 1999; 274(14): 9327 - 9334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Meierhans and R. K. Allemann The N-terminal Methionine Is a Major Determinant of the DNA Binding Specificity of MEF-2C J. Biol. Chem., October 2, 1998; 273(40): 26052 - 26060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Saviola, R. R. Seabold, and R. F. Schleif DNA Bending by AraC: a Negative Mutant J. Bacteriol., August 15, 1998; 180(16): 4227 - 4232. [Abstract] [Full Text]
|
|
|
|
|
|
S.-T. Liu, W.-Z. Chang, H.-M. Cao, H.-L. Hu, Z.-H. Chen, F.-D. Ni, H.-F. Lu, and G.-F. Hong A HU-like Protein Binds to Specific Sites within nod Promoters of Rhizobium leguminosarum J. Biol. Chem., August 7, 1998; 273(32): 20568 - 20574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Romine, J. R. Wood, L. A. Lamia, P. Prendergast, D. P. Edwards, and A. M. Nardulli The High Mobility Group Protein 1 Enhances Binding of the Estrogen Receptor DNA Binding Domain to the Estrogen Response Element Mol. Endocrinol., May 1, 1998; 12(5): 664 - 674. [Abstract] [Full Text]
|
|
|
|
|
|
K. Y. Rhee, D. F. Senear, and G. W. Hatfield Activation of Gene Expression by a Ligand-induced Conformational Change of a Protein-DNA Complex J. Biol. Chem., May 1, 1998; 273(18): 11257 - 11266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. ADHYA, M. GEANACOPOULOS, D.E.A. LEWIS, S. ROY, and T. AKI Transcription Regulation by Repressosome and by RNA Polymerase Contact Cold Spring Harb Symp Quant Biol, January 1, 1998; 63(0): 1 - 10. [Abstract] [PDF]
|
|
|
|
 |
|
 C. M. HAQQ and P. K. DONAHOE Regulation of Sexual Dimorphism in Mammals Physiol Rev, January 1, 1998; 78(1): 1 - 33. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Giese, J. Pagel, and R. Grosschedl Functional analysis of DNA bending and unwinding by the high mobility group domain of LEF-1 PNAS, November 25, 1997; 94(24): 12845 - 12850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Lazennec, T. R. Ediger, L. N. Petz, A. M. Nardulli, and B. S. Katzenellenbogen Mechanistic Aspects of Estrogen Receptor Activation Probed with Constitutively Active Estrogen Receptors: Correlations with DNA and Coregulator Interactions and Receptor Conformational Changes Mol. Endocrinol., August 1, 1997; 11(9): 1375 - 1386. [Abstract] [Full Text]
|
|
|
|
|
|
A. K. Nagaich, E. Appella, and R. E. Harrington DNA Bending Is Essential for the Site-specific Recognition of DNA Response Elements by the DNA Binding Domain of the Tumor Suppressor Protein p53 J. Biol. Chem., June 6, 1997; 272(23): 14842 - 14849. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. A. Leonard, N. Rajaram, and T. K. Kerppola Structural basis of DNA bending and oriented heterodimer binding by the basic leucine zipper domains of Fos and Jun PNAS, May 13, 1997; 94(10): 4913 - 4918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. McCormick, T. Badalian, and D. E. Fisher The leucine zipper may induce electrophoretic mobility anomalies without DNA bending PNAS, December 10, 1996; 93(25): 14434 - 14439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Akiyama and M. E. Hogan Microscopic DNA Flexibility Analysis. PROBING THE BASE COMPOSITION AND ION DEPENDENCE OF MINOR GROOVE COMPRESSION WITH AN ARTIFICIAL DNA BENDING AGENT J. Biol. Chem., November 15, 1996; 271(46): 29126 - 29135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Rousseau, M. Bétermier, M. Chandler, and R. Alazard Interactions between the Repressor and the Early Operator Region of Bacteriophage Mu J. Biol. Chem., April 19, 1996; 271(16): 9739 - 9745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Blakely and D Sherratt Determinants of selectivity in Xer site-specific recombination. Genes & Dev., March 15, 1996; 10(6): 762 - 773. [Abstract] [PDF]
|
|
|
|
|
|
S. Cal and B. A. Connolly The EcoRV Modification Methylase Causes Considerable Bending of DNA upon Binding to Its Recognition Sequence GATATC J. Biol. Chem., January 12, 1996; 271(2): 1008 - 1015. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Howard, W. C. Nelson, and S. W. Matson Stepwise Assembly of a Relaxosome at the F Plasmid Origin of Transfer J. Biol. Chem., November 24, 1995; 270(47): 28381 - 28386. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Jin, J. Mead, T. Li, C. Wolberger, and A. K. Vershon Altered DNA Recognition and Bending by Insertions in the alpha2 Tail of the Yeast a1/alpha2 Homeodomai n Heterodimer Science, October 13, 1995; 270(5234): 290 - 293. [Abstract] [PDF]
|
|
|
|
|
|
P L Sheridan, C T Sheline, K Cannon, M L Voz, M J Pazin, J T Kadonaga, and K A Jones Activation of the HIV-1 enhancer by the LEF-1 HMG protein on nucleosome-assembled DNA in vitro. Genes & Dev., September 1, 1995; 9(17): 2090 - 2104. [Abstract] [PDF]
|
|
|
|
|
|
L. Zulianello, P. van Ulsen, P. van de Putte, and N. Goosen Participation of the Flank Regions of the Integration Host Factor Protein in the Specificity and Stability of DNA Binding J. Biol. Chem., July 28, 1995; 270(30): 17902 - 17907. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Schaper and W. Messer Interaction of the Initiator Protein DnaA of Escherichia coli with Its DNA Target J. Biol. Chem., July 21, 1995; 270(29): 17622 - 17626. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Shore, L. Bisset, J. Lakey, J. P. Waltho, R. Virden, and A. D. Sharrocks Characterization of the Elk-1 ETS DNA-binding Domain J. Biol. Chem., March 17, 1995; 270(11): 5805 - 5811. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kim, S. Klooster, and D. J. Shapiro Intrinsically Bent DNA in a Eukaryotic Transcription Factor Recognition Sequence Potentiates Transcription Activation J. Biol. Chem., January 20, 1995; 270(3): 1282 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Strauss and L. Maher 3rd DNA bending by asymmetric phosphate neutralization Science, December 16, 1994; 266(5192): 1829 - 1834. [Abstract] [PDF]
|
|
|
|
|
|
D. Erie, G Yang, H. Schultz, and C Bustamante DNA bending by Cro protein in specific and nonspecific complexes: implications for protein site recognition and specificity Science, December 2, 1994; 266(5190): 1562 - 1566. [Abstract] [PDF]
|
|
|
|
|
|
S Natesan and M Z Gilman DNA bending and orientation-dependent function of YY1 in the c-fos promoter. Genes & Dev., December 1, 1993; 7(12b): 2497 - 2509. [Abstract] [PDF]
|
|
|
|
|
|
T T Paull, M J Haykinson, and R C Johnson The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures. Genes & Dev., August 1, 1993; 7(8): 1521 - 1534. [Abstract] [PDF]
|
|
|
|
|
|
S Kim and A Landy Lambda Int protein bridges between higher order complexes at two distant chromosomal loci attL and attR Science, April 10, 1992; 256(5054): 198 - 203. [Abstract] [PDF]
|
|
|
|
|
|
T. Kerppola and T Curran DNA bending by Fos and Jun: the flexible hinge model Science, November 22, 1991; 254(5035): 1210 - 1214. [Abstract] [PDF]
|
|
|
|
|
|
S. Schultz, G. Shields, and T. Steitz Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees Science, August 30, 1991; 253(5023): 1001 - 1007. [Abstract] [PDF]
|
|
|
|
|
|
T T Stenzel, T MacAllister, and D Bastia Cooperativity at a distance promoted by the combined action of two replication initiator proteins and a DNA bending protein at the replication origin of pSC101. Genes & Dev., August 1, 1991; 5(8): 1453 - 1463. [Abstract] [PDF]
|
|
|
|
|
|
J W Gober and L Shapiro Integration host factor is required for the activation of developmentally regulated genes in Caulobacter. Genes & Dev., September 1, 1990; 4(9): 1494 - 1504. [Abstract] [PDF]
|
|
|
|
|
|
L Moitoso de Vargas, S Kim, and A Landy DNA looping generated by DNA bending protein IHF and the two domains of lambda integrase Science, June 23, 1989; 244(4911): 1457 - 1461. [Abstract] [PDF]
|
|
|
|
|
|
M. van Beest, D. Dooijes, M. van de Wetering, S. Kjaerulff, A. Bonvin, O. Nielsen, and H. Clevers Sequence-specific High Mobility Group Box Factors Recognize 10-12-Base Pair Minor Groove Motifs J. Biol. Chem., August 25, 2000; 275(35): 27266 - 27273. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Bash, J. M. Vargason, S. Cornejo, P. S. Ho, and D. Lohr Intrinsically Bent DNA in the Promoter Regions of the Yeast GAL1-10 and GAL80 Genes J. Biol. Chem., January 5, 2001; 276(2): 861 - 866. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. T. Lewis, A. Andreucci, and B. S. Nikolajczyk PU.1-mediated Transcription Is Enhanced by HMG-I(Y)-dependent Structural Mechanisms J. Biol. Chem., March 16, 2001; 276(12): 9550 - 9557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Le Chatelier, L. Janniere, S. D. Ehrlich, and D. Canceill The RepE Initiator Is a Double-stranded and Single-stranded DNA-binding Protein That Forms an Atypical Open Complex at the Onset of Replication of Plasmid pAMbeta 1 from Gram-positive Bacteria J. Biol. Chem., March 23, 2001; 276(13): 10234 - 10246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. H. Kaplan, R.-T. Zong, R. F. Herrscher, R. H. Scheuermann, and P. W. Tucker Transcriptional Activation by a Matrix Associating Region-binding Protein. CONTEXTUAL REQUIREMENTS FOR THE FUNCTION OF BRIGHT J. Biol. Chem., June 8, 2001; 276(24): 21325 - 21330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Preiss, A. Argentaro, A. Clayton, A. John, D. A. Jans, T. Ogata, T. Nagai, I. Barroso, A. J. Schafer, and V. R. Harley Compound Effects of Point Mutations Causing Campomelic Dysplasia/Autosomal Sex Reversal upon SOX9 Structure, Nuclear Transport, DNA Binding, and Transcriptional Activation J. Biol. Chem., July 20, 2001; 276(30): 27864 - 27872. [Abstract] [Full Text] [PDF]
|
|