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Nucleic Acids Research, 1988, Vol. 16, No. 21 10323-10338
© 1988

CHEMISTRY

Interactions of water-soluble metalloporphyrins with nucleic acids studied by resonance Raman spectroscopy

Jinghua H. Schneider, Junichi Odo and Kazuo Nakamoto*

Todd Wehr Chemistry Building, Marquette University Milwaukee, WI 53233, USA

* To whom correspondence should be addressed

Received June 27, 1988. Accepted September 23, 1988.

The resonance Raman spectra of water-soluble porphyrins, M(TMpy-P4) (M = Cu(II), Ni(II) and Co(III)) and their mixtures with poly(dG-dC)2, poly(dA-dT)2 and calf thymus and salmon DNAs were measured using a divided rotating cell to determine the magnitudes of frequency shift and intensity variation resulting from M(TMpy-P4)-nuleic acid interactions. Bands II(Cß-H bending, {small tilde}1100 cm–1 ) and VIII (Cß-Cß stretch, {small tilde}1570 cm show a large and small upward shift, respectively, when Cu(TMpy-P4) and Ni(TMpy-P4) are intercalated at the G-C sites. In contrast, these bands show a small upward and downward shift, respectively, when Co(TMpy-P4) is groove-ound at the A-T sies of nucleic acids. Both Bands V ({small tilde}1260 cm) and IX({small tilde}l646 cm ) which originate in the N-methylpyridyl group always show small downward shifts due to coulombic interaction between the N-CH3+ group of TMpy-P4 and the P02 group of the nucleic acid.


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