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Nucleic Acids Research, 1988, Vol. 16, No. 4 1517-1528
© 1988

Articles

An oligopurine sequence bias occurs in eukaryotic viruses

Anne M. Beasty and Michael J. Behe

Department of Chemistry, Lehigh University Seeley Mudd Building no.6, Bethlehem, PA 18015, USA

Received January 7, 1988. Accepted January 21, 1988.

Twenty four DNA and RNA viral nucleotide sequences, comprising over 346 kilobases, have been analyzed for the occurence of strings of contiguous purine or pyrimidine residues. On average strings greater than or equal to 10 contiguous purines or pyrimidines are found three and a half times more frequently than would be expected for a random distribution of bases. Detailed analysis of the 172 kilobase Epstein-Barr viral sequence shows that the bias in favor of contiguous purine residues increases with the length of the purine string. These findings are similar to those seen for genomic DNA from higher eukaryotes (1). In contrast no overrepresentation of oligopurine or oligopyrimidine strings is observed in 52 kilobases from eight bacteriophage and E. coli DNA sequences.


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