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Nucleic Acids Research, 1988, Vol. 16, No. 7 3005-3012
© 1988

Articles

v-jun is a transcriptional activator, but not in all cell-lines

J.L. Imler, E. Ugarte, C. Wasylyk and B. Wasylyk

Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génetique de I'INSERM, Institut de Chimie Biologique, Faculté de Médecine 11 rue Humann, 67085 Strasbourg Cédex, France

Received January 25, 1988. Accepted March 1, 1988.

The recently isolated v-jun oncogene encodes a protein with sequence homology to the transcription factor APl, as well as a similar DNA binding specificity. We show, by expressing v-jun in F9 embryocarcinoma cells, that v-jun is also a transcriptional activator. However, v-jun expression does not activate transcription in several other cell-lines, suggesting that cell-specific factors are required for v-jun activity.


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