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Nucleic Acids Research, 1988, Vol. 16, No. 9 4111-4120
© 1988

Articles

Codon preference reflects mistranslational constraints: a proposal

David T. McPherson

Monsanto Company 700 Chesterfield Village Pkwy, St Louis, MO 63198, USA

Received December 8, 1987. Revised April 8, 1988. Accepted April 8, 1988.

Following the observation of lysine for arginine misincorporation at the poor choice codon arg-AGA, a comparison of codon usage patterns for highly expressed mRNA's in E. coli provides a basis for the proposal that the major codon preference is subject to mistranslational constraints. In addition, the codons are utilized, as well as arranged, to provide a hydropathically conservative amino acid as the most probable replacement resulting from a mistranslational event.


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