Nucleic Acids Research, 1989, Vol. 17, No. 12 4637-4646
© 1989
MOLECULAR BIOLOGY |
DNA nucleotide sequence analysis of the immediate-early gene of pseudorabies virus
USDA, Agricultural Research Service. National Animal Disease Center Ames, IA 50010, USA
Received February 24, 1989. Revised May 11, 1989. Accepted May 11, 1989.
The complete DNA sequence coding for the immediate-early protein (IE180) of pseudorabies virus was determined. The coding region of IE180 is 4380 nucleotides for 1460 amino acid residues. G+C content of the non-coding portion of the IE gene is 70.3% while the G+C content of the coding portion is considerably higher at 80.1 %. Correspondingly, codons consisting mainly of Gs and Cs are favored. Clusters of amino acid homologies are observed among IE180 of pseudorabies virus, ICP4 of herpes simplex virus type-1 and IE140 of varicella-zoster virus, and are organized similarly in all three polypeptides. Functions exhibited by IE180 are assigned, tentatively, to structural domains of the molecule by analogy to the HSV-1 ICP4 polypeptide.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. H. Kuddus and N. A. DeLuca DNA-Dependent Oligomerization of Herpes Simplex Virus Type 1 Regulatory Protein ICP4 J. Virol., September 1, 2007; 81(17): 9230 - 9237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Pomeranz, A. E. Reynolds, and C. J. Hengartner Molecular Biology of Pseudorabies Virus: Impact on Neurovirology and Veterinary Medicine Microbiol. Mol. Biol. Rev., September 1, 2005; 69(3): 462 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gomez-Sebastian and E. Tabares Negative regulation of herpes simplex virus type 1 ICP4 promoter by IE180 protein of pseudorabies virus J. Gen. Virol., August 1, 2004; 85(8): 2125 - 2130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Hagglund and B. Roizman Role of ICP0 in the Strategy of Conquest of the Host Cell by Herpes Simplex Virus 1 J. Virol., March 1, 2004; 78(5): 2169 - 2178. [Full Text] [PDF]
|
|
|
|
|
|
B. G. Klupp, C. J. Hengartner, T. C. Mettenleiter, and L. W. Enquist Complete, Annotated Sequence of the Pseudorabies Virus Genome J. Virol., January 1, 2004; 78(1): 424 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Delhon, M. P. Moraes, Z. Lu, C. L. Afonso, E. F. Flores, R. Weiblen, G. F. Kutish, and D. L. Rock Genome of Bovine Herpesvirus 5 J. Virol., October 1, 2003; 77(19): 10339 - 10347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Taharaguchi, S. Yoshino, K. Amagai, and E. Ono The latency-associated transcript promoter of pseudorabies virus directs neuron-specific expression in trigeminal ganglia of transgenic mice J. Gen. Virol., August 1, 2003; 84(8): 2015 - 2022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Sato, H. Ito, S. Hinchliffe, M. H. Sommer, L. Zerboni, and A. M. Arvin Mutational Analysis of Open Reading Frames 62 and 71, Encoding the Varicella-Zoster Virus Immediate-Early Transactivating Protein, IE62, and Effects on Replication In Vitro and in Skin Xenografts in the SCID-hu Mouse In Vivo J. Virol., May 15, 2003; 77(10): 5607 - 5620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Fuchs, H. Granzow, B. G. Klupp, M. Kopp, and T. C. Mettenleiter The UL48 Tegument Protein of Pseudorabies Virus Is Critical for Intracytoplasmic Assembly of Infectious Virions J. Virol., June 5, 2002; 76(13): 6729 - 6742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Bruce and K. W. Wilcox Identification of a Motif in the C Terminus of Herpes Simplex Virus Regulatory Protein ICP4 That Contributes to Activation of Transcription J. Virol., January 1, 2002; 76(1): 195 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Kinchington, K. Fite, A. Seman, and S. E. Turse Virion Association of IE62, the Varicella-Zoster Virus (VZV) Major Transcriptional Regulatory Protein, Requires Expression of the VZV Open Reading Frame 66 Protein Kinase J. Virol., October 1, 2001; 75(19): 9106 - 9113. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. I. Tussie-Luna, D. Bayarsaihan, F. H. Ruddle, and A. L. Roy Repression of TFII-I-dependent transcription by nuclear exclusion PNAS, July 3, 2001; 98(14): 7789 - 7794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Parkinson and R. D. Everett Alphaherpesvirus Proteins Related to Herpes Simplex Virus Type 1 ICP0 Induce the Formation of Colocalizing, Conjugated Ubiquitin J. Virol., June 1, 2001; 75(11): 5357 - 5362. [Abstract] [Full Text]
|
|
|
|
|
|
J. Parkinson and R. D. Everett Alphaherpesvirus Proteins Related to Herpes Simplex Virus Type 1 ICP0 Affect Cellular Structures and Proteins J. Virol., November 1, 2000; 74(21): 10006 - 10017. [Abstract] [Full Text]
|
|
|
|
|
|
W. Fuchs, C. Ehrlich, B. G. Klupp, and T. C. Mettenleiter Characterization of the replication origin (OriS) and adjoining parts of the inverted repeat sequences of the pseudorabies virus genome J. Gen. Virol., June 1, 2000; 81(6): 1539 - 1543. [Abstract] [Full Text]
|
|
|
|
|
|
P. A. Bates and N. A. DeLuca The Polyserine Tract of Herpes Simplex Virus ICP4 Is Required for Normal Viral Gene Expression and Growth in Murine Trigeminal Ganglia J. Virol., September 1, 1998; 72(9): 7115 - 7124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K J Martin, J W Lillie, and M R Green Transcriptional activation by the pseudorabies virus immediate early protein. Genes & Dev., December 1, 1990; 4(12b): 2376 - 2382. [Abstract] [PDF]
|
|