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Nucleic Acids Research, 1989, Vol. 17, No. 14 5751-5764
© 1989

MOLECULAR BIOLOGY

A point mutation in a mitocbondrial tRNA gene abolishes its 3' end processing

E. Zennaro, S. Francisci, A. Ragnini, L. Frontali and M.Bolotin- Fukuhara1

Department of Cell and Developmental Biology, University of Rome Italy 1Laboratoire de Génétique Moléculaire, Université Paris-Sud, Orsay, France

Received March 23, 1989. Accepted June 23, 1989.

A temperature sensitive mutation mapping in the tRNA region ofthe mitochondrial genome of S.cerevisiae has been found toabolish 3' processing of tRNA**p. Mutant cells grown for a few generations at the non-permissivetemperature were found to specifically lack mature tRNAp and toaccumulate 3' unprocessed precursors of this tRNA. The accumulation of precursors of other mitochondrial tRNAs wasalso observed under the same conditions. After longer incubationtimes, a generalized decrease of mitochondrial transcripts couldbe observed. The mutation was genetically mapped in a limited regionsurrounding the tRNA**p gene and found, by sequencing, to consistof a C-T transition at position 61 of the tRNA**p gene.


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