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Nucleic Acids Research, 1989, Vol. 17, No. 17 6809-6819
© 1989

MOLECULAR BIOLOGY

A novel germ-line JK transcript starting immediately upstream of JK1

Lise Leclercq*, Petra Butkeraitis and Michael Reth*

Institute of Genetics, University of Cologne Weyertal 121, D-5000 Köln 41, FRG

Received July 10, 1989. Accepted August 2, 1989.

Germ-line transcripts of the immunoglobulin (Ig) and T cell receptor loci are thought to be involved in the control of V gene rearrangement by rendering these loci accessible to the recombinases. We have analyzed the transcriptional activity of germ-line K alleles in two bone marrow-derived Abelson murine leukemia virus transformed pre-B cells: 300-19, a null cell line, and P a µ-producing line. We found a novel germ-line JK transcript starting immediately upstream of JK1 and spliced to CK. The potential role of this transcript in the opening of the Ig K locus as well as in the ordered usage of JK segments is discussed.

*Present address: Max-Planck-Institut für Immunbiologie, Stübeweg 51, D-7800 Freiburg, FRG


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