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Nucleic Acids Research, 1989, Vol. 17, No. 18 7315-7324
© 1989

MOLECULAR BIOLOGY

Transcriptional trans-repression by the c-myb proto-oncogene product

Hideki Nakagoshi1,3, Takahiro Nagase1,2, Yoshio Ueno3 and Shunsuke Ishii1

1Laboratory of Molecular Genetics, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN) Tsukuba, Ibaraki 305 2Frontier Research Programs, Tsukuba Life Science Center, The Institute of Physical and Chemical Research (RIKEN) Tsukuba, Ibaraki 305 3Department of Pharmaceutical Sciences, Science University of Tokyo Shinjuku-ku, Tokyo 162, Japan

Received May 30, 1989. Revised August 22, 1989. Accepted August 22, 1989.

We report that the c-myb protein binds to another site, MBS-l1, in the SV4O enhancer with low affinity. In co-transfection experiments with a c-myb expression plasmid, tandem repeats of the sequence containing the MBS-I1 site induced c-myb-dependent transcriptional repression. Results of mutational analyses of the sequence around the MBS-II site suggested that the c-myb protein represses transcription by competing with another trans-activator. These results indicate the c-myb protein can regulate transcription not only positively but also negatively.


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