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Nucleic Acids Research, 1989, Vol. 17, No. 19 7623-7630
© 1989

MOLECULAR BIOLOGY

Polymers of random short oligonucleotides detect polymorphic loci in the human genome

Gilles Vergnaud

Laboratoire de Génétique Moléculaire, Centre d'Etudes du Bouchet BP no. 3, 91710 Vert-le-Petit, France

Received July 18, 1989. Revised September 5, 1989. Accepted September 5, 1989.

Polymers of random 14 mer oligonucleotides are shown to detect discrete loci in the human genome. Eighteen different synthetic tandem repeats of random 14 base-pair units (STRs) have been generated and all of them turn out to detect polymorphic loci on southern blots of human DNA samples, presumably corresponding to a variable number of tandem repeats (VNTR). This finding suggests that minisatellites are a major component of the human genome and are strongly associated with the generation of genetic variability. In addition, it should open new strategies to make new polymorphic probes available.


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