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Nucleic Acids Research, 1989, Vol. 17, No. 19 7631-7642
© 1989

MOLECULAR BIOLOGY

Structural alterations of the BCR and ABL genes in Phl positive acute leukemias with rearrangements in the BCR gene first intron: further evidence implicating Alu sequences in the chromosome translocation

S.J. Chen, Z. Chen, M.-P. Font1, L. d'Auriol2, C.-J. Larsen and R. Berger*,

Unité INSERM U 301 and SDI CNRS no. 159541, Hôpital Saint-Louis 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France 1Unité INSERM U 93, Hôpital Saint-Louis 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France 2Laboratoire d'Hématologie Experimentale CNRS, Hôpital Saint-Louis 1 Avenue Claude Vellefaux, 75475 Paris Cedex 10, France

*To whom correspondence should be addressed

Received July 13, 1989. Revised August 29, 1989. Accepted August 29, 1989.

In the Philadelphia positive bcr negative acute leukemias (Phl+bcr– AL), the chromosomal breakpoints on chromosome 22 have been shown clustered within 10.8kb (bcr2) and 5kb (bcr3) fragments of the first intron of the BCR gene. We previously reported that the breakpoints were localized in Alu repeats on chromosomes 9 and 22 in a Phl+bcr– acute lymphoblastic leukemia with a rearrangement involving bcr2. Molecular data of two other Phl translocations, one a Phl+bcr– acute myeloblastic leukemia in the bcr2 region, and the other an acute lymphoblastic leukemia in the bcr3 region are presented. In the former, the breakpoints on chromosomes 9 and 22 are localized in Alu repeats, in regions with two inverted Alu sequences, as in our previously reported case. In the second leukemia, the breakpoints are not located in Alu sequences, but such repeats are found in their vicinity. The implications of these findings are discussed.


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