Nucleic Acids Research, 1989, Vol. 17, No. 21 8569-8580
© 1989
MOLECULAR BIOLOGY |
RNA-binding properties of influenza A virus matrix protein M1
Sir William Dunn School of Pathology, University of Oxford South Parks Road, Oxford OX1 3RE, UK
Received July 17, 1989. Revised September 6, 1989. Accepted September 6, 1989.
The matrix protein (M1) of influenza A virus, which has a critical role in viral assembly and can inhibit the viral transcriptase complex, has the ability to bind RNA. The RNA-binding property of M1 is specific for single-stranded RNA, like that of influenza nucleoprotein (NP) and shows similar sensitivity to pH and to salt concentration. M1:RNA complexes are stable, once formed, to competition from excess single-stranded RNA. The possible location of the RNA-binding regions in the M1 protein is discussed.
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