Nucleic Acids Research, 1989, Vol. 17, No. 5 1915-1931
© 1989
MOLECULAR BIOLOGY |
Structure, expression and regulation of the murine 4F2 heavy chain
The Howard Hughes Medical Institute and Department of Internal Medicine, University of Michigan Medical Center and The Ann Arbor VA Hospital 1150 W.Medical Center Drive, MSRB 1, Room 4510, Ann Arbor, MI 48109, USA 1Dana Farber Cancer Institute, Harvard Medical School Boston, MA 02115, USA
*To whom correspondence should be addressed
Received November 22, 1988. Revised January 31, 1989. Accepted January 31, 1989.
The murine 4F2 molecule is a 125 kilodalton disulfide-linked heterodimeric cell-surface glycoprotein which has been shown to be involved in the processes of cellular activation and proliferation (1). To elucidate the structure, expression, and regulation of the 4F2 molecule, a murine 4F2 heavy chain (4F2HC) cDNA has been isolated and structurally characterized. The murine 4F2HC is a 526 amino acid (aa) type II membrane glycoprotein which is composed of a 75 aa N-terminal intracytoplasmic region, a single hydrophobic putative transmembrane domain, and a 428 aa C-terminal extracellular domain. Comparison with the human 4F2HC cDNA reveals the highest degree of sequence identity within the transmembrane and intracytoplasmic domains. Northern blot analyses have demonstrated that the 4F2HC gene is expressed at relatively high levele in adult testis, lung, brain, kidney, and spleen, and at significantly lower levels in adult liver and cardiac and skeletal muscle. Studies designed to elucidate the pattern of regulation of the murine 4F2HC gene have demonstrated that it is induced during the process of cell activation, but is subsequently expressed at constant levels throughout the cell cycle in exponentially growing cells.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  K. Kaira, N. Oriuchi, Y. Otani, K. Shimizu, S. Tanaka, H. Imai, N. Yanagitani, N. Sunaga, T. Hisada, T. Ishizuka, et al. Fluorine-18-{alpha}-Methyltyrosine Positron Emission Tomography for Diagnosis and Staging of Lung Cancer: A Clinicopathologic Study Clin. Cancer Res., November 1, 2007; 13(21): 6369 - 6378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Yan, G. Dalmasso, S. Sitaraman, and D. Merlin Characterization of the human intestinal CD98 promoter and its regulation by interferon-{gamma} Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G535 - G545. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Cerec, C. Piquet-Pellorce, H. A.A. Aly, A.-M. Touzalin, B. Jegou, and F. Bauche Multiple Pathways for Cationic Amino Acid Transport in Rat Seminiferous Tubule Cells Biol Reprod, February 1, 2007; 76(2): 241 - 249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. H. Cornish, L. V. Sinclair, and D. A. Cantrell Differential regulation of T-cell growth by IL-2 and IL-15 Blood, July 15, 2006; 108(2): 600 - 608. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Henderson, E. A. Collis, A. C. Mackinnon, K. J. Simpson, C. Haslett, R. Zent, M. Ginsberg, and T. Sethi CD98hc (SLC3A2) Interaction with {beta}1 Integrins Is Required for Transformation J. Biol. Chem., December 24, 2004; 279(52): 54731 - 54741. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. C. Rintoul, R. C. Buttery, A. C Mackinnon, W. S. Wong, D. Mosher, C. Haslett, and T. Sethi Cross-Linking CD98 Promotes Integrin-like Signaling and Anchorage-independent Growth Mol. Biol. Cell, August 1, 2002; 13(8): 2841 - 2852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-i. Hosoya, M. Tomi, S. Ohtsuki, H. Takanaga, S. Saeki, Y. Kanai, H. Endou, M. Naito, T. Tsuruo, and T. Terasaki Enhancement of L-Cystine Transport Activity and Its Relation to xCT Gene Induction at the Blood-Brain Barrier by Diethyl Maleate Treatment J. Pharmacol. Exp. Ther., July 1, 2002; 302(1): 225 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Matejuk, J. Dwyer, A. Zamora, A. A. Vandenbark, and H. Offner Evaluation of the Effects of 17{beta}-Estradiol (17{beta}-E2) on Gene Expression in Experimental Autoimmune Encephalomyelitis Using DNA Microarray Endocrinology, January 1, 2002; 143(1): 313 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chillaron, R. Roca, A. Valencia, A. Zorzano, and M. Palacin Heteromeric amino acid transporters: biochemistry, genetics, and physiology Am J Physiol Renal Physiol, December 1, 2001; 281(6): F995 - F1018. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Papetti and I. M. Herman Controlling Tumor-Derived and Vascular Endothelial Cell Growth : Role of the 4F2 Cell Surface Antigen Am. J. Pathol., July 1, 2001; 159(1): 165 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. P. Rajan, W. Huang, R. Kekuda, R. L. George, J. Wang, S. J. Conway, L. D. Devoe, F. H. Leibach, P. D. Prasad, and V. Ganapathy Differential Influence of the 4F2 Heavy Chain and the Protein Related to b0,+ Amino Acid Transport on Substrate Affinity of the Heteromeric b0,+ Amino Acid Transporter J. Biol. Chem., May 5, 2000; 275(19): 14331 - 14335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Rossier, C. Meier, C. Bauch, V. Summa, B. Sordat, F. Verrey, and L. C. Kuhn LAT2, a New Basolateral 4F2hc/CD98-associated Amino Acid Transporter of Kidney and Intestine J. Biol. Chem., December 3, 1999; 274(49): 34948 - 34954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Nakamura, M. Sato, H. Yang, F. Miyagawa, M. Harasaki, K. Tomita, S. Matsuoka, A. Noma, K. Iwai, and N. Minato 4F2 (CD98) Heavy Chain Is Associated Covalently with an Amino Acid Transporter and Controls Intracellular Trafficking and Membrane Topology of 4F2 Heterodimer J. Biol. Chem., January 29, 1999; 274(5): 3009 - 3016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Mannion, T. V. Kolesnikova, S. H. Lin, S. Wang, N. L. Thompson, and M. E. Hemler The Light Chain of CD98 Is Identified as E16/TA1 Protein J. Biol. Chem., December 11, 1998; 273(50): 33127 - 33129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. B. Deora, R. N. Ghosh, and S. S. Tate Progressive C-terminal Deletions of the Renal Cystine Transporter, NBAT, Reveal a Novel Bimodal Pattern of Functional Expression J. Biol. Chem., December 4, 1998; 273(49): 32980 - 32987. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. PALACIN, R. ESTEVEZ, J. BERTRAN, and A. ZORZANO Molecular Biology of Mammalian Plasma Membrane Amino Acid Transporters Physiol Rev, October 1, 1998; 78(4): 969 - 1054. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Estévez, M. Camps, A. M. Rojas, X. Testar, R. Devés, M. A. Hediger, A. Zorzano, and M. Palacín The amino acid transport system y+L/4F2hc is a heteromultimeric complex FASEB J, October 1, 1998; 12(13): 1319 - 1329. [Abstract] [Full Text]
|
|
|
|
|
|
Y. Kanai, H. Segawa, K.-i. Miyamoto, H. Uchino, E. Takeda, and H. Endou Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98) J. Biol. Chem., September 11, 1998; 273(37): 23629 - 23632. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. DEVES and C. A. R. BOYD Transporters for Cationic Amino Acids in Animal Cells: Discovery, Structure, and Function Physiol Rev, April 1, 1998; 78(2): 487 - 545. [Abstract] [Full Text] [PDF]
|
|