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Nucleic Acids Research, 1989, Vol. 17, No. 5 2023-2042
© 1989

MOLECULAR BIOLOGY

The mitochondrial plasmid from Neurospora intermedia strain Labelle-1b contains a long open reading frame with blocks of amino acids characteristic of reverse transcriptases and related proteins

Suchira Pande, Edmond G. Lemire and Frank E. Nargang*

Department of Genetics, University of Alberta Edmonton, Alberta T6G 2E9, Canada

*To whom correspondence should be addressed

Received October 20, 1988. Revised January 27, 1989. Accepted January 27, 1989.

We have determined the DNA sequence of the 4070 base pair mitochondrial plasmid from the Labelle-1b strain of Neurosoora intermedia. Analysis of the sequence revealed that the plasmid contains a long open reading frame (ORF) that could encode a protein of up to 1151 amino acids. Codon usage in the long ORF shows no clear relationship to Neurospora mitochondrial genea, nuclear genes, nor to the ORF of a different Neurospora mitochondrial plasmid. The long ORF contains regions of similarity to yeast mitochondrial RNA polymerase as well as blocks of amino acids that are characteristic of reverse transcriptases and the ORFs of certain group II mtDNA introns (Michel and Lang, (1985) Nature 316, 641). The plasmid gives rise to specific transcripts, some of which may be unit length, and which carry the information for expression of the long ORF. The genetic organization and content of the plasmid suggest that it is related to mobile genetic elements.


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