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Nucleic Acids Research, 1989, Vol. 17, No. 6 2283-2300
© 1989

MOLECULAR BIOLOGY

Interaction of DNA-binding proteins with the tissue-specific human apolipoprotein-AII enhancer

Miguel A. Lucero*, Daniel Sanchez1, Alberto R. Ochoa, Franck Brunel, Georges N. Cohen, Francisco E. Baralle2 and Mario M. Zakin

Unité de Biochimie Cellulaire, lnstitut Pasteur 28 rue du Docteur Roux, 75724 Paris Cedex 15, France 1Sir William Dunn School of Pathology, University of Oxford UK 2Instituto Sieroterapico Milanese S.Belfanti Milan, Italy

*To whom correspondence should be addressed

Received January 5, 1989. Revised January 14, 1989. Accepted January 14, 1989.

The identification of the binding sites for liver nuclear proteins present in the enhancer that control the cell specific transcription of the human apolipoprotein AII gene is reported. Five adjacent binding Sites (motifs I to V) were identified. The motifs III, IV and V can be occupied differently by liver or HeLa nuclear proteins. Two hypersensitive zones (between motifs II-III and IV-V) are present only when liver nuclear extracts were tested. A first characterization of the factors reveal that motif IV interacts with the hepatic transcription factors Tf-LF1 (29) and LF-A1 (28, 30). A CCAAT binding protein, different from CTF/NF1. appears to bind to the motif II. The different binding sites share specific DNA sequences principally with 5' regulatory regions of other apolipoprotein genes.


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