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Nucleic Acids Research, 1989, Vol. 17, No. 8 3049-3056
© 1989

MOLECULAR BIOLOGY

Coordinate regulation of RNAs encoding two isoforms of the rat muscle nicotinic acetylcholine receptor (ß-subunit

Daniel Goldman* and Katherine Tamai

Mental Health Research Institute and Department of Biological Chemistry, University of Michigan Ann Arbor, MI 48109, USA

*To whom correspondence should be addressed

Received December 23, 1988. Revised March 1, 1989. Accepted March 1, 1989.

The nicotinic acetylcholine receptor (nAchR) mediates communication between nerve and skeletal muscle. The properties, levels and distribution of these receptors change during development of the neuromuscular junction. These changes may be due, in part, to expression of different gene products. We are using nuclease protection experiments and cDNA cloning to identify the RNA transcripts that encode nAchRs in rat muscle. This analysis has identified two ß-subunit mRNAs. Complementary DNAs corresponding to these two RNAs have been isolated from a rat skeletal muscle cDNA library. Based on nucleotide sequence analysis, these RNAs differ by 9 bases in their 5' coding sequence. The levels of both mRNAs change similarly during muscle development and upon denervation of adult skeletal muscle. These two ß-subunit RNAs probably result from the use of different exon/intron splice sites in the ß-subunit gene.


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