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Nucleic Acids Research, 1990, Vol. 18, No. 18 5521-5528
© 1990

CHEMISTRY

Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study

G.R. Clark+, D.G. Brown, M.R. Sanderson, T. Chwalinski, S. Neidle*, J.M. Veal1, R.L. Jones1, W.D. Wilson1,*, G. Zon2, E. Garman3 and D.I. Stuart3

Cancer Research Campaign Biomolecular Structure Unit, The Institute of Cancer Research Sutton, Surrey SM2 5NG, UK 1Department of Chemistry, Georgia State University Atlanta, GA 30303 2Applied Biosystems Inc Foster City, CA 94404 USA 3Laboratory of Molecular Biophysics, University of Oxford Oxford OX1 5QQ, UK

*To whom correspondence should be addressed

Received May 17, 1990. Revised August 16, 1990. Accepted August 16, 1990.

A combined crystal-structure determination and NMR analysis of the octanucleotide d(ATGCGCAT)2 is reported. The X-ray analysis shows that the structure is A-form duplex in crystal state. The NMR study shows that in solution this sequence is B-type. The conformational results from each technique are presented in detail. The implications of these findings in terms of conformational flexibility and ligand binding are discussed.

+Permanent address: Department of Chemistry, University of Auckland, Auckland, New Zealand


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