Skip Navigation

This Article
Right arrow Print PDF (4456K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (86)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Kendall, E.
Right arrow Articles by Campbell, R.D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kendall, E.
Right arrow Articles by Campbell, R.D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1990, Vol. 18, No. 24 7251-7257
© 1990

Articles

Human major histocompatibility complex contains a new cluster of genes between the HLA-D and complement C4 loci

E. Kendall, C.A. Sargent1 and R.D. Campbell*

MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford South Parks Road, Oxford OX1 3QU 1Department of Pathology, University of Cambridge Tennis Court Road, Cambridge CB2 1QP, UK

*To whom correspondence should be addressed

Received October 2, 1990. Revised November 9, 1990. Accepted November 9, 1990.

A new cluster of genes has been defined in the human Major Histocompatibility Complex class III region. The seven novel genes, G12 to G18, are localised in a 160 kb segment of DNA extending from the complement gene cluster towards HLA-DR. The genes were identified by isolation of cDNA clones using cosmid genomic inserts as hybridisation probes, and by the detection of the corresponding transcripts in Northern blot analysis. Characterisation of the cosmid genomic DNA inserts, in conjunction with pulsed field gel electrophoresis analysis of uncloned DNA, for the presence of clustered sites for infrequently cutting restriction endonucleases has revealed that at least 5 of the 7 genes are associated with HTF-islands. These unmethylated CpG-rich sequences are frequently found at the 5' ends of ubiquitously expressed genes. Together with previously published data 36 genes have now been defined in a 680kb stretch of DNA within the MHC. With one gene approximately every 20kb of DNA this represents the most densely packed region of the human genome so far characterised, and is of major significance in relation to the mapping and sequence analysis of the rest of the genome.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Cell Sci.Home page
R. Christova, T. Jones, P.-J. Wu, A. Bolzer, A. P. Costa-Pereira, D. Watling, I. M. Kerr, and D. Sheer
P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFN{gamma}
J. Cell Sci., September 15, 2007; 120(18): 3262 - 3270.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Wu, F. Iwata, J. A. Grass, C. S. Osborne, L. Elnitski, P. Fraser, O. Ohneda, M. Yamamoto, and E. H. Bresnick
Molecular Determinants of NOTCH4 Transcription in Vascular Endothelium
Mol. Cell. Biol., February 15, 2005; 25(4): 1458 - 1474.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
E. Volpi, E Chevret, T Jones, R Vatcheva, J Williamson, S Beck, R. Campbell, M Goldsworthy, S. Powis, J Ragoussis, et al.
Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei
J. Cell Sci., January 5, 2000; 113(9): 1565 - 1576.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
B. Aguado and R. D. Campbell
Characterization of a Human Lysophosphatidic Acid Acyltransferase That Is Encoded by a Gene Located in the Class III Region of the Human Major Histocompatibility Complex
J. Biol. Chem., February 13, 1998; 273(7): 4096 - 4105.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
M G Olavesen, A F Davies, S J Broxholme, J L Wixon, G Senger, D Nizetic, R D Campbell, and J Ragoussis
An integrated map of human chromosome 6p23.
Genome Res., November 1, 1995; 5(4): 342 - 358.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.