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Nucleic Acids Research, 1990, Vol. 18, No. 24 7389-7396
© 1990

Articles

Transcription regulates oxolinic acid-induced DNA gyrase cleavage at specific sites on the E.coli chromosome

Guy Condemine and Cassandra L. Smith1,*

Laboratoire de Microbiologie INSA Bat 406, 20 Avenue Albert Einstein, 69621 Villeurbanne, France 1Human Genome Center, Lawrence Berkeley Laboratory and Department of Molecular and Cell Biology, Universfty of California Berkeley, CA 94720, USA

*To whom correspondence should be addressed

Received July 31, 1990. Revised November 13, 1990. Accepted November 13, 1990.

Prominent DNA gyrase-mediated cleavage sites, induced by oxolinic acid, occur at specific, but infrequent, locations on the Escherichia coli chromosome. These sites, which we call toposites, may represent high affinity DNA gyrase binding sites or may mark chromosomal regions that accumulate superhelical stress. Toposites are usually grouped in 5 to 10 kb clusters that are mostly 50 to 100 kb apart. The total number of clusters on the chromosome is between 50 and 100. The location of sites depends on the local sequence. The extent of DNA gyrase cleavage at toposites can be strongly modulated by transcription occurring at as far as 35 kb away.


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