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Nucleic Acids Research, 1990, Vol. 18, No. 8 2163-2170
© 1990

MOLECULAR BIOLOGY

Chaos game representation of gene structure

H.Joel Jeffrey

Nothern Illinois University DeKalb, lL.USA

Received June 5, 1989. Revised March 20, 1990. Accepted March 20, 1990.

This paper presents a new method for representing DNA sequences. It permits the representation and investigation of patterns in sequences, visually revealing previously unknown structures. Based on a technique from chaotic dynamics, the method produces a picture of a gene sequence which displays both local and global patterns. The pictures have a complex structure which varies depending on the sequence. The method is termed Chaos Game Representation (CGR). CGR raises a new set of questions about the structure of DNA sequences, and is a new tool for investigating gene structure.


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