Skip Navigation

This Article
Right arrow Print PDF (3583K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Kere, J.
Right arrow Articles by de la Chapelle, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kere, J.
Right arrow Articles by de la Chapelle, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1991, Vol. 19, No. 10 2755-2759
© 1991

GENOME STRUCTURE AND MAPPING

Refinement of human chromosome 7 map around the proalpha2(I)collagen gene by long-range restriction mapping

Juha Kere*, Ritva Tolvanen, Helen Donis-Keller1 and Albert de la Chapelle

Department of Medical Genetics, University of Helsinki 00290 Helsinki, Finland 1Department of Genetics, Washington University School of Medicine St Louis, MO 63110, USA

* To whom correspondence should be addressed at Department of Molecular Microbiology, Washington University School of Medicine, Box 8230, St Louis, MO 63110, USA

Received December 21, 1990. Revised April 15, 1991. Accepted April 15, 1991.

The physical proximity of the closely linked proalpha2(I)collagen (COL1A2) and erythropoietin (EPO) genes and five loci with no known function was studied by long-range restriction mapping experiments using pulsed-field gel electrophoresls. COL1A2 and D7S64 were found to be within 100 kb of each other, providing a new informative marker for linkage studies with respect to COL1A2. D7S15 and D7S79 were within 350 kb of each other. The physical distance between COL1A2 and EPO was determined to be at least 600 kb. Two CpG rich islands were recognized within 600 kb of COL1A2, suggesting that other genes might lie in the vicinity of COL1A2.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.