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Nucleic Acids Research, 1975, Vol. 2, No. 1 113-120
© 1975

Articles

Accessibility of chromatin to DNA polymerase I and location of the F1 histone

Roy Saffhill and Ruth F. Itzhaki

Paterson Laboratories, Christie Hospital and Holt Radium Institute Withington, Manchester M20 9BX, UK

The effect of prebound poly-L-lysine upon the template activity of DNA, chromatin and F1 histone-depleted chromatin for E.coli DNA polymerase I has been investigated. Measurements have been made in the absence and presence of 0.1M NaCl. From the results we conclude that only ca 60% of the polylysine-accessible DNA, i.e. 22% of the total DNA of the chromatin, is accessible to the DNA polymerase I and that ca. 30% of the polylysine-accessible DNA, i.e. 11% of the total DNA, is associated with the F1 histone.


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