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Nucleic Acids Research, 1975, Vol. 2, No. 1 121-130
© 1975

Articles

Antiviral activity of polynucleotides: copolymers of inosinic acid and N2-dimethylguanylic or 2-methylthioinosinic acid

Erik De Clercq, Masao Hattori* and Morio Ikehara*

*Rega Institute for Medical Research, University of Leuven Leuven, Belgium

Accepted December 6, 1974.

Complexes of poly(C) with2 copolymers of inosinic acid containing various amounts of mismatched bases (m2G or ms2 I) have been examined for direct resistance to virus infection, interferon induction and toxicity in two different cell cultures (primary rabbit kidney cells and mouse L-9292cells). Complexes in which 20 % of the hypoxanthine bases were replaced by m2G or ms2 I were partially active whereas complexes in which 40 % or more of the hypoxanthine bases were replaced by the odd bases were entirely inactive The decrease in biological activity observed upon intrusion of m22G or ms2 I in the poly(I) strand of poly(I).poly(C) closely paralleled the amount of odd bases introduced irrespective of the system employed to assess the biological activity (resistance to virus infection, interferon induction or toxicity.


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