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Nucleic Acids Research, 1975, Vol. 2, No. 3 327-346
© 1975

Articles

On the statistical significance of primary structural features found in DNA-protein interaction sites

Gene Dykes, Robert Bambara, Kenneth Marians and Ray Wü

Biochemistry, Molecular and Cell Biology, Wing Hall, Cornell University Ithaca, New York 14853, USA

Received December 16, 1974. Probabilities of occurrence for a number of the symmetries and other sequence regularities found in DNA-protein interaction site sequences have been calculated for segments of random DNA sequence. Results show that many of the symmetrical and repetitive features seen in these interaction sites are likely to have occurred by chance. Other features are so unlikely to have occurred by chance that they are probably involved in the DNA-protein interaction processes.


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