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Nucleic Acids Research, 1975, Vol. 2, No. 4 459-467
© 1975

Articles

A proton magnetic resonance investigation of the glycosyl torsion angle of uracil nucleosides and nucleotides

Thomas Schleich*, Ted R. Lusebrink**, Bradford P. Cross/,* and Neil P. Johnson*

*Division of Natural Sciences, University of California Santa Cruz, California 95064, USA

Received November 6, 1974.

The use of line-shape decomposition techniques permitted the small 5-bond (5J51') and 4-bond (4J61') proton-proton coupling constants of a series of uracil nucleosides and nucleotides to be determined accurately. From an analysis of these coupling constants we have determined that the uracil base is in a predominantly anti conformation in aqueous solution and the mean position is not substantially altered by phosphate substitution at the 2', 3', or 5' positions, by changing the furanose stereochemistry from a ribose to a deoxyribose or an arabinose, or by an increase in temperature of 43°C.

**International Business Machines Research Laboratories, San Jose, California 95193, USA Deceased May 1974

/Present address: International Atomic Energy A gency, PO Box 645, A-1011, Vienna, Austria


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